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Cytotoxicity on V79 and HL60 Cell Lines by Thiolated--Cyclodextrin-Au/Violacein Nanoparticles

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Abstract:

In vitro cytotoxicity of a supramolecular system composed by violacein complexed by -cyclodextrin-thiol-protected gold nanoparticles (violacein @ -CD–S(CH2)6–S–Au) on V79 and HL60 cell lines is described. The gold nanoparticles were prepared and modified in a single step involving reduction of tetrachloroaurate ions with sodium borohydride in the presence of thiol derivatized -cyclodextrin. Inclusion complexation of violacein into cyclodextrin cavities occurred by mixing an aqueous solution of the gold nanoparticles with an acetone solution of violacein, being evidenced by UV/visible absorption spectroscopy. According to cell viability measurements based on the MTT assay (3-(4,5-dimethylthiazole-2-yl)-2,5-biphenyl tetrazolium bromide) the supramolecular system was found to maintain the cytotoxic effects compared to free violacein on HL60 cells and in addition is less cytotoxic to normal (V79) cells.

Keywords: ANTITUMOR; DRUG DELIVERY; GOLD NANOPARTICLES; HL60; IN VITRO CYTOTOXICITY; VIOLACEIN

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2005.041

Publication date: September 1, 2005

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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