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Nanoelectrodes Fabricated from Electron Beam Deposited Carbon as Potential Electrochemical Neuronal Probes

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Abstract:

Nanoscale electrochemical probes with dimensions as small as 50 nm in diameter and 1–2 micrometers in length have been fabricated using electron beam deposition on the apex of conventional micron size electrodes. The electroactive region is limited to the extreme tip of the nanoprobe by coating with insulating polymer and re-opening of the coating at the extreme tip. We show that our nanoelectrodes are capable of recording neuronal signals from neurons of the mouse hippocampal slice preparation. It is conceivable that nanoprobes can be potentially valuable for the direct measurement of electrical signals at a single presynaptic terminal or postsynaptic site.

Keywords: BRAIN SLICES; CELLULAR PROBES; ELECTROCHEMICAL; ELECTRON BEAM DEPOSITION; HIPPOCAMPAL SLICES; NANOELECTRODES; NANOPROBES; NEURON SIGNALS; NON-CONDUCTIVE COATING; SINGLE SYNAPSE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2005.035

Publication date: September 1, 2005

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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