Skip to main content

Loading of 5-Fluorouracil to Poly(ethyl-2-cyanoacrylate) Nanoparticles with a Magnetic Core

Buy Article:

$113.00 plus tax (Refund Policy)

Abstract:

In this article we describe a detailed investigation of the capabilities of poly(ethyl-2-cyanoacrylate, PE-2-CA) and magnetite/PE-2-CA core/shell nanoparticles to load the antitumour drug 5-fluorouracil (5-FU). The nuclear magnetic resonance and secondary ion mass spectrometry analysis of the polymeric particles allowed us to conclude about their composition and molecular weight distribution. The hysteresis cycles of both magnetite and magnetite/polymer particles demonstrated that the polymer shell reduces the magnetic responsiveness of the particles but keeps unchanged their soft ferrimagnetic character. The effect of synthesis residues on the absorbance of supernatants was considered in the loading measurement methodology, because of their potentially perturbing influence on the determination of 5-FU concentration in solution. We found first of all that most of the drug incorporation took place as absorption or entrapment in the polymeric network, with little contribution of surface adsorption, in turn only detectable by means of electrophoretic mobility measurements. Another remarkable finding is that neither ethyl-2-cyanoacrylate nor dextran-70 concentrations had significant effects on the drug absorption per unit mass of polymer. On the contrary, the acidity of the medium needs to be controlled to avoid formation of macroaggregates, because of a too fast polymerization, and to reach a significant absorption of 5-FU. The optimum conditions found were used to perform evaluations of 5-FU loading to polymeric and composite particles, and it was demonstrated that under such conditions the drug loading attainable with our magnetic carriers is comparable to that found for different polymer particles in this and other works.

Keywords: 5-FLUOROURACIL; ANTICANCER DRUG; BIODEGRADABLE POLYMERS; COATING; CORE/SHELL COLLOIDAL PARTICLES; DRUG DELIVERY SYSTEMS; DRUG LOADING; ELECTROPHORESIS; MAGNETIC CARRIER TECHNOLOGY; MAGNETIC COLLOIDS; POLY(ETHYL-2-CYANOACRYLATE)

Document Type: Research Article

DOI: https://doi.org/10.1166/jbn.2005.029

Publication date: 2005-06-01

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more