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Micelles from Poly(ethylene glycol)–Phosphatidyl Ethanolamine Conjugates (Peg-Pe) as Pharmaceutical Nanocarriers for Poorly Soluble Drug Camptothecin

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Abstract:

Nanoparticulate drug carriers, polymeric micelles made from conjugates of polyethylene glycol and phosphatidylethanolamine (PEG-PE) have been successfully used for the solubilization of the poorly soluble anticancer drug camptothecin (CPT). CPT-loaded micelles had the size of ca. 15 nm, were stable upon storage, and firmly retained the incorporated drug. The cytotoxicity of CPT-loaded PEG-PE micelles in different cell culture models was significantly higher than that of the free drug. The CPT incorporated PEG-PE micelles may represent a novel development in the poorly soluble drug delivery systems.

Keywords: CAMPTOTHECIN; CYTOTOXICITY; MICELLES; NANOCARRIERS; POLYMER-LIPID CONJUGATES; POORLY SOLUBLE DRUGS; SOLUBILIZATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2005.030

Publication date: June 1, 2005

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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