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Sol–Gel-Coated Poly(methyl methacrylate) as a Substrate for Localized Surface Plasmon Resonance Biosensors

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Chemical modification of poly(methyl methacrylate) (PMMA) surfaces has been achieved by base hydrolysis of the surface ester group and subsequent reactive coating of amine-functionalized sol–gel silica films. Such substrates have been used to form self-assembled monolayers of gold nanospheres or gold nanoshells for localized surface plasmon resonance (LSPR) biosensing. Sensing sensitivities of the LSPR biosensors based on PMMA substrates and the traditionally used glass substrates have been compared. In addition, a LSPR biosensor based on PMMA substrate has also been constructed to detect transferrin. Results show that replacement of glass substrates by PMMA substrates does not deteriorate the sensing performance of those LSPR biosensors.


Document Type: Research Article


Publication date: 2005-06-01

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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