Home >> Genome Letters, Volume 2, Numbers 1-2

Helicobacter Vaccine Development Based on Global Approaches

Authors: Bumann D.1; Jungblut P.R.2; Meyer T.F.1

Source: Genome Letters, Volume 2, Numbers 1-2, March 2003 , pp. 88-92(5)

Publisher: American Scientific Publishers

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Abstract:

The development of an efficacious human Helicobacter vaccine remains a challenge. Here we describe how promising antigens can be selected through global approaches, including in silico predictions, transcriptomics, and proteomics. The recent identification of two highly protective Helicobacter-specific antigens highlights the utility of a multi-parameter approach.

Keywords: HELICOBACTER PYLORI; VACCINE; ANTIGEN SELECTION; SURFACE PROTEOME; SECRETOME; IMMUNOPROTEOME.

Document Type: Research article

DOI: http://dx.doi.org/10.1166/gl.2003.000

Affiliations: 1: Department of Molecular Biology, Max-Planck-Institut für Infektionsbiologie, D-10117 Berlin, Germany 2: Central Core Facility for Protein Analysis, Max-Planck-Institut für Infektionsbiologie, D-10117Berlin, Germany

Publication date: 2003-03-01

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