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In Vitro Cytotoxic Effect of Formulated Semecarpus Ghee Nanoemulsion on Human Cervical Cancer (SiHa) Cells

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Abstract:

Cytotoxic effect of Semecarpus ghee nanoemulsion on human cervical cancer cells has been determined by adopting MTT assay and specific staining techniques. The cultured cervical (SiHa) cancer cells treated with Semecarpus ghee nanoemulsion suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features. In conclusion, Semecarpus ghee nanoemulsion produced antiproliferative and morphological effects on SiHa cells appear to be target-specific killing of cells which gives further lead to study apoptotic pathways as target for cervical cancer therapy. This study provided a scientific basis for the anti-tumor property of Semecarpus ghee nanoemulsion with respect to cervical cancer.

Keywords: APOPTOSIS; CERVICAL CANCER; CYTOTOXICITY; JC-1 DYE; NANOEMULSION; NECROSIS; SEMECARPUS GHEE

Document Type: Research Article

DOI: https://doi.org/10.1166/asl.2012.2037

Publication date: 2012-03-01

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