Skip to main content

Development of Cerium Oxide Nanoparticles and Its Cytotoxicity in Prostate Cancer Cells

Buy Article:

$105.00 plus tax (Refund Policy)

Cerium oxide nanoparticles were synthesized by hydrothermal and hydrolysis methods. Cerous (4+ oxide nanoparticles was produced by hydrothermal method and ceric (3+ oxide nanoparticles were produced by hydrolysis method. The different synthesis routes adopted helped in synthesizing nanoparticles of similar size but exhibiting different properties. Detailed characterization of the nanoparticles proved that the synthesized cerium oxide nanoparticles were different in their stoichiometry. The selective toxicity of cerium oxide towards the normal and the cancer cell lines was evaluated. The nanoparticles were found to be nontoxic towards normal cell lines (L929) but cytotoxic towards prostate cancer cell lines (PC-3) as analyzed by MTT assay. Cellular uptake was confirmed by the conjugation of cerium oxide nanoparticle with a fluorescent dye rhodamine- 123 followed by optical detection of the uptake.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: CELLULAR UPTAKE; CERIUM OXIDE NANOPARTICLES; CYTOTOXICITY; HYDROTHERMAL; MTT ASSAY; PROSTATE CANCER CELL LINE; STOICHIOMETRY

Document Type: Research Article

Publication date: 2012-03-01

More about this publication?
  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more