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Monoolein Cubic Phase Containing Ionizable Aromatic Compounds-Loaded β-Cyclodextrin Polymers: FITC-Dextran Release Property

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Abstract:

β-Cyclodextrin (β-CD) polymer (PβCD) was prepared by reacting β-CD and Epichlorohydrin (EPI) at the molar ratio of 1:7 in a strong alkalic condition. And then, inclusion complex of PβCD and diaminobenzophenone (DABP, an alkalic aromatic compound) (DABP-PβCD) was prepared by dissolving DABP in PβCD solution (1% (w/w), pH 7.4). In addition, inclusion complex of PβCD and naphthaleneacetic acid (NAA, an acidic aromatic compound) (NAA-PβCD) was prepared in PβCD solution (1% (w/w), pH 5.0). And then, monoolein (MO) cubic phase containing DABP-PβCD and NAA-PβCD was prepared by a melt-hydration method. The release of FITC-dextran from the cubic phase was somewhat suppressed at neutral condition, possibly due to an extensive complexation between DABP-PβCD and NAA-PβCD in the water channels of the cubic phase.

Keywords: COMPLEXATION; CONTROLLED RELEASE; CUBIC PHASE; CYCLODEXTRIN; IONIZABLE AROMATIC COMPOUND

Document Type: Research Article

DOI: https://doi.org/10.1166/asl.2012.1972

Publication date: 2012-01-01

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