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Monoolein Cubic Phase Containing Ionizable Aromatic Compounds-Loaded β-Cyclodextrin Polymers: FITC-Dextran Release Property

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Abstract:

β-Cyclodextrin (β-CD) polymer (PβCD) was prepared by reacting β-CD and Epichlorohydrin (EPI) at the molar ratio of 1:7 in a strong alkalic condition. And then, inclusion complex of PβCD and diaminobenzophenone (DABP, an alkalic aromatic compound) (DABP-PβCD) was prepared by dissolving DABP in PβCD solution (1% (w/w), pH 7.4). In addition, inclusion complex of PβCD and naphthaleneacetic acid (NAA, an acidic aromatic compound) (NAA-PβCD) was prepared in PβCD solution (1% (w/w), pH 5.0). And then, monoolein (MO) cubic phase containing DABP-PβCD and NAA-PβCD was prepared by a melt-hydration method. The release of FITC-dextran from the cubic phase was somewhat suppressed at neutral condition, possibly due to an extensive complexation between DABP-PβCD and NAA-PβCD in the water channels of the cubic phase.

Keywords: COMPLEXATION; CONTROLLED RELEASE; CUBIC PHASE; CYCLODEXTRIN; IONIZABLE AROMATIC COMPOUND

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/asl.2012.1972

Publication date: January 1, 2012

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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