Arginine an Enhancer of Gold Nanoparticle Induced Blocking of S-Phase Cell Cycle in HL60
Abstract:Gold nanosurface has the potential to act as an anticancer agent. In this report we show that arginine conjugated gold nanoparticles can be cytotoxic to leukemia cells through the perturbation of the cell cycle. Pro-myelotic leukemia cell HL60 that can differentiate to its terminal lineage, can be arrested at the S phase of the cell cycle by such nanoparticles. Importantly, arginine, a non-toxic metabolite, serves as a dose dependent enhancer of gold nanoparticle induced cytotoxicity.
Document Type: Research Article
Publication date: November 1, 2011
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