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Arginine an Enhancer of Gold Nanoparticle Induced Blocking of S-Phase Cell Cycle in HL60

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Abstract:

Gold nanosurface has the potential to act as an anticancer agent. In this report we show that arginine conjugated gold nanoparticles can be cytotoxic to leukemia cells through the perturbation of the cell cycle. Pro-myelotic leukemia cell HL60 that can differentiate to its terminal lineage, can be arrested at the S phase of the cell cycle by such nanoparticles. Importantly, arginine, a non-toxic metabolite, serves as a dose dependent enhancer of gold nanoparticle induced cytotoxicity.

Keywords: ARGININE; CELL CYCLE BLOCKER; GOLD NANOPARTICLE; HL60; S PHASE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/asl.2011.3163

Publication date: November 1, 2011

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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