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Free Content Neuroimaging of Primary Progressive Aphasia Variants

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Primary progressive aphasia is a neurodegenerative syndrome, with the common feature being aphasia in the absence of marked impairment in other cognitive and behavioral domains. Three primary subtypes have been described: 1) nonfluent or agrammatic primary progressive aphasia, 2) semantic primary progressive aphasia, and 3) logopenic primary progressive aphasia. Although sharing the same primary progressive aphasia designation, these variants show very diverse clinical phenotypes, molecular pathologies, and neuroimaging findings. This review presented current knowledge of clinical phenotypes, molecular pathologies, and multimodal neuroimaging findings, including MR imaging, FDG-PET, amyloid PET, tau PET, and DTI. With increased awareness of the spectrum of neuroimaging abnormalities, the neuroradiologist can potentially add valuable information in correctly categorizing these patients and their underlying pathologies.

Learning Objective: Describe the clinical features and imaging findings that distinguish the variants of primary progressive aphasia.
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Keywords: AD = Alzheimer disease; FA = fractional anisotropy; FTLD = frontotemporal lobar degeneration; FTLD-TDP = frontotemporal lobar degeneration-TAR DNA binding; FTLD-tau = tau-type frontotemporal lobar degeneration; PPA = primary progressive aphasia; lvPPA = logopenic variant primary progressive aphasia; naPPA = nonfluent or agrammatic primary progressive aphasia; svPPA = semantic variant primary progressive aphasia

Document Type: Research Article

Publication date: 01 February 2018

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  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities. CME credit for review articles may be claimed up to 3 years after an article's publication date. Visit https://members.asnr.org/webcast/content/course_list.asp?src=Neurographics to view all available CME courses.
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