Authors: Wingo, Jonathan E.; Low, David A.; Keller, David M.; Crandall, Craig G.

Source: Aviation, Space, and Environmental Medicine, Volume 79, Number 12, December 2008 , pp. 1081-1085(5)

Publisher: Aerospace Medical Association

Abstract:

Wingo JE, Low DA, Keller DM, Crandall CG. Cutaneous vascular responses to hypercapnia during whole-body heating. Aviat Space Environ Med 2008; 79:1081-5.

Introduction: Hypercapnia may be encountered in lung disease as well as during situations involving rebreathing of previously expired air (e.g., occupational diving). Inhibitory effects of elevated arterial carbon dioxide partial pressure on the central nervous system may result in impaired thermoregulation. This study tested the hypothesis that in heat-stressed subjects, cutaneous vascular responsiveness [expressed as cutaneous vascular conductance (CVC)] would be reduced during hypercapnic exposure. Methods: Four men and three women (mean ± SD; age: 35 ± 7 yr) rested supine while wearing a tube-lined suit perfused with 34°C water (normothermia). Following normothermic data collection, 50°C water was perfused through the suit to increase internal temperature approximately 1°C (whole-body heating). In both thermal conditions, a normoxic-hypercapnic (5% CO₂, 21% O₂, balance N₂) gas mixture was inspired while forearm skin blood flux (laser-Doppler flowmetry) was measured continuously and was used for calculation of CVC (skin blood flux/mean arterial pressure). Results: End-tidal CO₂ increased similarly throughout hypercapnic exposure during both normothermic and whole-body heating conditions (7.9 ± 2.4 and 8.3 ± 1.9 mmHg, respectively). However, CVC was not different between normocapnia and hypercapnia under either thermal condition (normothermia: 0.42 ± 0.24 vs. 0.39 ± 0.21 flux units/mmHg for normocapnia and hypercapnia, respectively; heat stress: 1.89 ± 0.67 vs. 1.92 ± 0.63 flux units/mmHg for normocapnia and hypercapnia, respectively). Discussion: Based on these findings, mild hypercapnia is unlikely to impair heat dissipation by reducing cutaneous vasodilation.

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Keywords: thermoregulation; heat stress; skin blood flow; carbon dioxide

Document Type: Research article

DOI: http://dx.doi.org/10.3357/ASEM.2403.2008

Publication date: 2008-12-01

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• The peer-reviewed monthly journal, Aviation, Space, and Environmental Medicine (ASEM) provides contact with physicians, life scientists, bioengineers, and medical specialists working in both basic medical research and in its clinical applications. It is the most used and cited journal in its field. ASEM is distributed to more than 80 nations.
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