Authors: Montcalm-Smith, Elizabeth; Caviness, James; Chen, Ye; McCarron, Richard M.

Source: Aviation, Space, and Environmental Medicine, Volume 78, Number 2, February 2007 , pp. 87-93(7)

Publisher: Aerospace Medical Association

Abstract:

Montcalm-Smith E, Caviness J, Chen Y, McCarron RM. Stress biomarkers in a rat model of decompression sickness. Aviat Space Environ Med 2007; 78:8793.

Introduction: Immune reactivity, stress responses, and inflammatory reactions may all contribute to pathogenic mechanisms associated with decompression sickness (DCS). Currently, there are no biomarkers for DCS. This research examined if DCS is associated with increased levels of biomarkers associated with vascular function, early/non-specific stress responses, and hypothalamic-pituitary-adrenal (HPA) axis stress responses. Methods: Rats undergoing a test dive to 175 ft of seawater (fsw) (6.2 ATA) for 60 min with a rapid decompression were observed for DCS (ambulatory deficit). Animals exercised on a rotating cage (∼3 m · min⁻¹) throughout the dive and subsequent 30-min observation period. All animals were euthanized and blood and tissue samples (brain, liver, lung) were collected for analysis of CRP and ET-1 by ELISA and stress markers by PCR. Results: HO-1 and HSP-70 increased in the brain, and HO-1, Egr-1, and iNOS increased in the lungs of animals with DCS. There was no difference in any stress marker in the liver, or in serum levels of CRP or ET-1. Conclusions: The results demonstrate that < 30 min after surfacing, there are genomic changes in animals with DCS compared with animals not showing signs of DCS. Identification of specific markers of DCS may permit use of such biomarkers as predictors of DCS susceptibility and/or occurrence.

References: 38 references open in new window

Articles that cite this article?

Keywords: C-reactive protein; hemeoxygenase-1; heat shock proteins; endothelin-1

Document Type: Research article

Publication date: 2007-02-01

More about this publication?

• The peer-reviewed monthly journal, Aviation, Space, and Environmental Medicine (ASEM) provides contact with physicians, life scientists, bioengineers, and medical specialists working in both basic medical research and in its clinical applications. It is the most used and cited journal in its field. ASEM is distributed to more than 80 nations.
• Information for Authors
• Subscribe to this Title
• Membership Information
• Information for Advertisers
• Submit Articles
• 2011 Annual Meeting and Event Information
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Transportation ,  Medicine (General) ,  Public Health
• By this author: Montcalm-Smith, Elizabeth ;  Caviness, James ;  Chen, Ye ;  McCarron, Richard M.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers