Provider: Ingenta Connect Database: Ingenta Connect Content: application/x-research-info-systems TY - ABST AU - Crist, Lindsey AU - Dixon, Dave TI - Considerations for Dofetilide Use in the Elderly JO - The Consultant Pharmacist PY - 2014-04-01T00:00:00/// VL - 29 IS - 4 SP - 270 EP - 274 KW - TdP = Torsades de pointes KW - PAC = Premature atrial contractions KW - Drug interactions KW - BP = Blood pressure KW - HCTZ = Hydrochlorothiazide KW - Thiazide KW - IU = International units KW - HTN = Hypertension KW - Diuretics KW - Dofetilide KW - AF = Atrial fibrillation KW - ECG = Electrocardiogram KW - Chlorthalidone KW - CPC = Cardiopharmacotherapy clinic N2 - This case describes an 85-year-old African-American female with atrial arrhythmias on dofetilide maintenance therapy who presented to an ambulatory cardiology clinic with hypotension. The pharmacist identified a potential major drugdrug interaction between dofetilide and the thiazide diuretic, chlorthalidone. Because of the patient's hypotension, it was decided to discontinue chlorthalidone to avoid the potential drug interaction with dofetilide. A systolic BP goal of 140-145 mmHg was later achieved and maintained with the addition of low-dose amlodipine, in addition to her lisinopril. This case highlights important considerations for prescribing and monitoring dofetilide and reviews hypertension management in the elderly population. UR - https://www.ingentaconnect.com/content/ascp/tcp/2014/00000029/00000004/art00006 M3 - doi:10.4140/TCP.n.2014.270 UR - https://doi.org/10.4140/TCP.n.2014.270 ER -