Quetiapine for Sleep in Patients with Dementia
Abstract:Objective: To examine the use of quetiapine for sleep in patients with dementia admitted to a geriatric psychiatry ward.
Design: Retrospective cross-sectional study (January 2007 to December 2009).
Setting: Geriatric psychiatric unit located near a metropolitan city in North Carolina.
Participants: All patients admitted with a diagnosis of dementia who were also receiving quetiapine were eligible. One hundred one patients met the criteria and were included in the study.
Main Outcome Measures: Descriptive statistics defining quetiapine prescribing. Based on a priori criteria, quetiapine was considered to be used for sleep if it were prescribed: 1) only at bedtime, as needed, for sleep, 2) once daily, only at bedtime, or 3) multiple times daily, but with at least 75% of the daily dose administered at bedtime.
Results: Forty-three of the 101 patients included in the study were prescribed quetiapine, probably for sleep. Quetiapine, when used as a sedative-hypnotic, was generally employed at doses between 50 mg and 100 mg nightly. Several published studies report beneficial sleep-promoting effects of quetiapine and other atypical antipsychotics for primary and secondary sleep complaints; however, most of these trials involve young and middle-aged adults, have diagnostic variability, and are limited methodologically.
Conclusion: Quetiapine prescribed as a sedative-hypnotic in patients with dementia, while common, is understudied and not without risk.
Document Type: Research Article
Publication date: October 1, 2010
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