Authors: Kassa, Jiri¹; Karasova, Jana Zdarova¹; Musilek, Kamil¹; Kuca, Kamil²; Jung, and Young-Sik³

Source: Toxicology Mechanisms and Methods, Volume 19, Number 3, March 2009 , pp. 232-238(7)

Publisher: Informa Healthcare

Abstract:

The potency of newly developed bispyridinium compounds (K117, K127) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oxime (obidoxime) using functional observational battery. The neuroprotective effects of atropine alone and atropine combined with one of three bispyridinium oximes (K117, K127, obidoxime) on rats poisoned with tabun at a sublethal dose (180 μg/kg i.m.; 80% of LD₅₀ value) were studied. Tabun-induced neurotoxicity was monitored using a functional observational battery and automatic measurement of motor activity at 24 h following tabun challenge. The results indicated that all tested oximes combined with atropine enabled tabun-poisoned rats to survive 24 h following tabun challenge while one tabun-poisoned rats died within 24 h after tabun poisoning when the rats were treated with atropine alone. Newly developed oxime K127 combined with atropine was the most effective in decreasing tabun-induced neurotoxicity in the case of sublethal poisonings among all oximes tested. Nevertheless, the differences of neuroprotective efficacy between K127 and obidoxime are not sufficient to replace obidoxime by K127 for the treatment of acute tabun poisonings.

Keywords: Atropine; Functional observational battery; Neurotoxicity; Oximes; Tabun

Document Type: Research article

DOI: http://dx.doi.org/10.1080/15376510802455362

Affiliations: 1: 1Department of Toxicology, Faculty of Military Health Sciences, Trebesska, Hradec Kralove, Czech Republic 2: 2Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska, Hradec Kralove, Czech Republic 3: 3Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusong, Daejeon, Korea

Publication date: 2009-03-01

More about this publication?

• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Ecology ,  Toxicology
• By this author: Kassa, Jiri ;  Karasova, Jana Zdarova ;  Musilek, Kamil ;  Kuca, Kamil ;  Jung, and Young-Sik

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers