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Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor

Authors: Wang, Lei1; Tong, Yin1; Chen, Zhimei2; Xu, Weilai1; Jin, Jie1

Source: Upsala Journal of Medical Sciences, Volume 115, Number 4, November 2010 , pp. 287-290(4)

Publisher: Informa Healthcare

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Abstract:

Abstract

Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor outcome. Interestingly, a hypophyseal tumor was detected simultaneously by magnetic resonance imaging in this case. We think it is probable that the tumor in the hypophysis might be associated with the ALCL.

Keywords: ALCL; ALK+; chromosomal translocation; hypophyseal tumor

Document Type: Case Report

DOI: http://dx.doi.org/10.3109/03009734.2010.500061

Affiliations: 1: 1Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China 2: 2Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China

Publication date: November 1, 2010

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