CLONAL MONOSOMY 7 AND 5q IN A CHILD WITH MYELODYSPLASTIC SYNDROME

Authors: Chantrain C.¹; Vermylen C.¹; Michaux L.²; Brichard B.¹; Cornu G.¹

Source: Pediatric Hematology and Oncology, Volume 17, Number 6, 1 September 2000 , pp. 505-509(5)

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Abstract:

The authors report the case of a 5-year-old boy referred for thrombocytopenia and neutropenia. Bone marrow examination showed a myelodysplasia with clonal monosomy7. The acceleration of the disease was marked by the appearance of an additional cytogenetic abnormality, i.e., the deletion of the long arm of chromosome 5 in the clonal cells. RAS genemutationwas not detected. Chemotherapy was started to achieve complete remission before a bone marrow transplatation. This treatment was complicated by a prolonged a plasia and the patient died of systemic mycotic infection.

Keywords: MONOSOMY; 7; 5q-; MYELODYSPLASIA; RAS; MUTATION

Language: English

Document Type: Research article

Affiliations: 1: Department of Pediatric Hematology and Oncology, Cliniques Universitaires St-Luc, University of Louvain, Brussels, Belgium 2: Department of Human Genetics, Cliniques Universitaires St-Luc, University of Louvain, Brussels, Belgium

Publication date: 2000-09-01

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