Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene
Source: Inhalation Toxicology, Volume 24, Number 11, September 2012 , pp. 689-697(9)
Publisher: Informa Healthcare
Abstract:The biological response to inhalation of secondary organic aerosol (SOA) was determined in rodents exposed to SOA derived from the oxidation of toluene, a precursor emitted from anthropogenic sources. SOA atmospheres were produced to yield 300 µg·m−3 of particulate matter (PM) plus accompanying gases. Whole-body exposures were conducted in mice to assess both pulmonary and cardiovascular effects. ApoE−/− mice were exposed for 7 days and measurements of TBARS and gene expression of heme-oxygenase-1 (HO-1), endothelin-1 (ET-1), and matrix metalloproteinase-9 (MMP-9) were made in aorta. Pulmonary inflammatory responses in both species were measured by bronchoalveolar lavage fluid (BALF) cell counts. No pulmonary inflammation was observed. A mild response was observed in mouse aorta for the upregulation of ET-1 and HO-1, with a trend for increased MMP-9 and TBARS, and. Overall, toluene-derived SOA revealed limited biological response compared with previous studies using this exposure protocol with other environmental pollutants.
Document Type: Research Article
Affiliations: 1: 1Lovelace Respiratory Research Institute, Albuquerque, NM, USA 2: 3Departments of Chemical Engineering and Environmental Science and Engineering, California Institute of Technology, Pasadena, CA, USA 3: 4Electric Power Research Institute, Palo Alto, CA, USA
Publication date: September 1, 2012