Is calprotectin a marker of tobacco smoke related inflammation?: a pilot study in children
Source: Inhalation Toxicology, Volume 24, Number 8, July 2012 , pp. 486-491(6)
Publisher: Informa Healthcare
Abstract:Context: Environmental tobacco smoke (ETS) related inflammation has an anorexigenic effect through affecting the release of appetite-modulating mediators, leptin and ghrelin. Elevated serum calprotectin levels are found in a variety of inflammatory conditions. Objective: To study the relation between ETS and body mass index (BMI), as well as serum levels of leptin, ghrelin and calprotectin. Materials and methods: A cross-sectional study was performed by searching the smoking status of parents. After filling in the questionnaires, parents were phoned and children were invited to supply fasting blood samples in order to measure serum levels of leptin, ghrelin and calprotectin, and to calculate their BMIs. Participant children were divided into Group 1 (n = 51), those who are not exposed to and Group 2 (n = 46), exposed to indoor ETS. Results: There were no statistical difference in BMI, leptin and ghrelin levels between Group 1 and Group 2 (p values are 0.85, 0.87 and 0.42, respectively), but serum calprotectin levels were statistically higher in Group 2 (p = 0.003). Discussion and conclusion: In this study serum levels of calprotectin were found to be higher in children with indoor ETS exposure where no relation was detected with BMI and serum levels of leptin and ghrelin. Increased serum levels of calprotectin might be an indicator of inflammation related to ETS exposure.
Document Type: Research Article
Affiliations: 1: 1Department of Pediatric Pulmonology 2: 2Department of Pediatrics 3: 3Department of Pediatric Allergy and Immunology 4: 4Department of Biochemistry, Near East University, Faculty of Medicine, Nicosia, North Cyprus
Publication date: July 2012