Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated mice
Source: Inhalation Toxicology, Volume 24, Number 6, May 2012 , pp. 373-381(9)
Publisher: Informa Healthcare
Abstract:Limonene is one of the main flavonoids which is reported to inhibit the inflammatory response by suppressing the production of reactive oxygen species. The aim of this study was to evaluate whether limonene can inhibit Dermatophagoides farinae-induced airway hyperresponsiveness (AHR), eosinophilic infiltration and other histological changes in the lung, T helper (Th) 2 cytokine production and airway remodeling in a mice model of asthma. Treatment with limonene significantly reduced the levels of IL-5, IL-13, eotaxin, MCP-1, and TGF-β1 in bronchoalveolar lavage fluid. The goblet cell metaplasia, thickness of airway smooth muscle, and airway fibrosis were markedly decreased in limonene-treated mice. Furthermore, AHR to acetylcholine was significantly abrogated in limonene-treated mice. These results indicate that limonene has a potential to reduce airway remodeling and AHR in asthma model.
Document Type: Research Article
Affiliations: 1: 1Department of Environmental Medicine, Kochi Medical School, Kohasu, Oko, Nankoku, Japan 2: 2Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan 3: 3Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe, Nankoku, Japan
Publication date: May 1, 2012