Authors: Lemos, Miriam¹; Diaz, Edgar A.¹; Gupta, Tarun¹; Kang, Choong-Min¹; Ruiz, Pablo²; Coull, Brent A.¹; Godleski, John J.¹; Gonzalez-Flecha, Beatriz¹

Source: Inhalation Toxicology, Volume 23, Supplement 2 to issue 1, August 2011 , pp. 75-83(9)

Publisher: Informa Healthcare

Abstract:

In vivo chemiluminescence (CL) is a measure of reactive oxygen species in tissues. CL was used to assess pulmonary and cardiac responses to inhaled aerosols derived from aged emissions of three coal-fired power plants in the USA. Sprague-Dawley rats were exposed to either filtered air or: (1) primary emissions (P); (2) ozone oxidized emissions (PO); (3) oxidized emissions ++ secondary organic aerosol (SOA) (POS); (4) neutralized oxidized emissions ++ SOA (PONS); and (5) control scenarios: oxidized emissions ++ SOA in the absence of primary particles (OS), oxidized emissions alone (O), and SOA alone (S). Immediately after 6 hours of exposure, CL in the lung and heart was measured. Tissues were also assayed for thiobarbituric acid reactive substances (TBARS). Exposure to P or PO aerosols led to no changes compared to filtered air in lung or heart CL at any individual plant or when all data were combined. POS caused significant increases in lung CL and TBARS at only one plant, and not in combined data from all plants; PONS resulted in increased lung CL only when data from all plants were combined. Heart CL was also significantly increased with exposure to POS only when data from all plants were combined. PONS increased heart CL significantly in one plant with TBARS accumulation, but not in combined data. Exposure to O, OS, and S had no CL effects. Univariate analyses of individual measured components of the exposure atmospheres did not identify any component associated with increased CL. These data suggest that coal-fired power plant emissions combined with other atmospheric constituents produce limited pulmonary and cardiac oxidative stress.

Keywords: Chemiluminescence; oxidative stress; heart; lung; ambient particles; source emissions

Document Type: Research article

DOI: http://dx.doi.org/10.3109/08958378.2011.601433

Affiliations: 1: 1Department of Environmental Health, Harvard School of Public Health, Boston, MA,USA 2: 2School of Public Health, University of Chile, Independencia, Santiago, Chile

Publication date: 2011-08-01

More about this publication?

• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Internal Medicine
• By this author: Lemos, Miriam ;  Diaz, Edgar A. ;  Gupta, Tarun ;  Kang, Choong-Min ;  Ruiz, Pablo ;  Coull, Brent A. ;  Godleski, John J. ;  Gonzalez-Flecha, Beatriz

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers