Pre- and postnatal exposure to low-dose diesel exhaust impairs murine spermatogenesis
Source: Inhalation Toxicology, Volume 23, Number 13, November 2011 , pp. 805-813(9)
Publisher: Informa Healthcare
Abstract:We investigated whether pre- and postnatal low-dose exposure to diesel exhaust (DE) affects male reproductive function in mice. The DE concentration is less than that indicated as the environmental quality standard for suspended particulate matter (SPM) in Japan. ICR mice were exposed prenatally to low-dose diesel exhaust (0.17 mg of DE particles/m3) through the airway for 8 h/day in an exposure chamber from gestational day 2 until the examination. In the DE-exposed groups, normal sperm morphology in the epididymis was reduced (p < 0.01), and seminiferous tubules showed degenerative changes in which the number of Sertoli cells was decreased (p < 0.01). Those changes were observed at 6 and 12 weeks of age. Furthermore, ultrastructural studies revealed an increase in damaged mitochondria in Sertoli cells (p < 0.001) and variform spermatozoa. These results indicate that pre- and postnatal exposure of low-dose DE is detrimental to Sertoli cell function and may cause abnormal spermatozoa.
Document Type: Research article
Affiliations: 1: 4Department of Hygiene Chemistry, Ohu University School of Pharmaceutical Sciences, Tomita-machi, Koriyama, Fukushima, Japan 2: 2Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Tokyo University of Science, Yamasaki, Noda, Chiba, Japan 3: 5The Research Institute of Tuberculosis, Matsuyama, Kiyose, Tokyo, Japan
Publication date: 2011-11-01