Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells
Source: Inhalation Toxicology, Volume 21, Supplement 1 to issue 1, July 2009 , pp. 123-130(8)
Publisher: Informa Healthcare
Abstract:Because vascular endothelial cell inflammation is critical in the development of cardiovascular pathology, we hypothesized that direct exposure of human aortic endothelial cells (HAECs) to ultrafine particles induces an inflammatory response. To test the hypothesis, we incubated HAECs for 4 h with different concentrations (0.001–50 μg/ml) of CeO2 nanoparticles and subsequently measured mRNA levels of the three inflammatory markers intercellular adhesion molecule 1 (ICAM-1), interleukin (IL)-8, and monocyte chemotactic protein (MCP-1) using real-time polymerase chain reaction (PCR). Ceria nanoparticles caused very little inflammatory response in HAECs, even at the highest dose. This material is apparently rather benign in comparison with Y2O3 and ZnO nanoparticles that we have studied previously. These results suggest that inflammation in HAECs following acute exposure to metal oxide nanoparticles depends strongly on particle composition.
Document Type: Research Article
Affiliations: 1: 1Department of Mechanical and Aeronautical Engineering, University of California, Davis, California 2: 2Department of Mechanical Engineering, University of California, Riverside, California, USA 3: 3Department of Mechanical Engineering, Texas A&M University, College Station, Texas, USA
Publication date: July 1, 2009