Authors: Ayres, Jon¹; Borm, Paul²; Cassee, Flemming³; Castranova, Vincent⁴; Donaldson, Ken⁵; Ghio, Andy⁶; Harrison, Roy⁷; Hider, Robert⁸; Kelly, Frank⁹; Kooter, Ingeborg¹⁰; Marano, Francelyne¹¹; Maynard, Robert¹²; Mudway, Ian¹³; Nel, Andre¹⁴; Sioutas, Constantinos¹⁵; Smith, Steve¹⁶; Baeza-Squiban, Armelle¹¹; Cho, Art¹⁴; Duggan, Sean¹⁷; Froines, John¹⁴

Source: Inhalation Toxicology, Volume 20, Number 1, February 2008 , pp. 75-99(25)

Publisher: Informa Healthcare

Abstract:

Background: There is a strong need for laboratory in vitro test systems for the toxicity of airborne particulate matter and nanoparticles. The measurement of oxidative stress potential offers a promising way forward. Objectives:Aworkshop was convened involving leading workers from the field in order to review the available test methods and to generate a Consensus Statement. Discussions: Workshop participants summarised their own research activities as well as discussion the relative merits of different test methods. Conclusions: In vitro test methods have an important role to play in the screening of toxicity in airborne particulate matter and nanoparticles. In vitro cell challenges were preferable to in vitro acellular systems but both have a potential major role to play and offer large cost advantages relative to human or animal inhalation studies and animal in vivo installation experiments. There remains a need to compare tests one with another on standardised samples and also to establish a correlation with the results of population-based epidemiology.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/08958370701665517

Affiliations: 1: Liberty Safe Work Research Centre, Foresterhill Road, Aberdeen, Scotland, United Kingdom 2: Centre of Expertise in Life Sciences (CEL), Zuyd University, Netherlands 3: Centre for Environmental Health Research, National Institute for Public Health and the Environment Bilthoven, The Netherlands 4: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA 5: Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK 6: Clinical Research Branch, Human Studies Facility, U.S. Environmental Protection Agency, Chapel Hill, North Carolina, USA 7: Division of Environmental Health & Risk Management, School of Geography, Earth and Environmental Sciences, Edgbaston, Birmingham, United Kingdom 8: School of Biomedical and Health Sciences, King's College, London, United Kingdom 9: Pharmaceutical Sciences, Franklin-Wilkins Building, London, United Kingdom 10: Department of Inhalation Toxicology, Centre for Environmental Health Research (MGO), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands 11: Laboratoire de Cytophysiologie et Toxicologie Cellulaire, Paris, France 12: Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chemical Hazards and Poisons Division(Headquarters), Chilton DIDCOT, Oxfordshire, United Kingdom 13: School of Biomedical &Health Sciences, Guy's Campus, London, United Kingdom 14: Department of Medicine at UCLA, Los Angeles, California, USA 15: Department of Civil and Environmental Engineering, Los Angeles, California, USA 16: Department of Life Sciences, King's College London, Strand, London, United Kingdom 17: School of Biomedical and Health Sciences, Guy's Campus, London, United Kingdom

Publication date: 2008-02-01

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• By this author: Ayres, Jon ;  Borm, Paul ;  Cassee, Flemming ;  Castranova, Vincent ;  Donaldson, Ken ;  Ghio, Andy ;  Harrison, Roy ;  Hider, Robert ;  Kelly, Frank ;  Kooter, Ingeborg ;  Marano, Francelyne ;  Maynard, Robert ;  Mudway, Ian ;  Nel, Andre ;  Sioutas, Constantinos ;  Smith, Steve ;  Baeza-Squiban, Armelle ;  Cho, Art ;  Duggan, Sean ;  Froines, John

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