Aspergillus fumigatus Challenge Increases Cytokine Levels in Nasal Lavage Fluid
Source: Inhalation Toxicology, Volume 18, Number 13, December 1 2006 , pp. 1033-1039(7)
Publisher: Informa Healthcare
Abstract:Several studies have shown an association between exposure in moisture-damaged buildings and adverse health effects. There are several indicator microbes of moisture damage, but Aspergillus fumigatus is one of the best-documented molds provoking health problems in different occupational conditions. We assessed whether inhalation of a commercial A. fumigatus solution would affect cytokine levels (tumor necrosis factor [TNF]-α, interleukin [IL]-1, IL-4, IL-6, interferon [IFN]-) in nasal lavage fluid (NAL) compared with that evoked by placebo challenge. Twenty-seven subjects were studied: 13 had occupational exposure in a moisture-damaged building, 4 were atopic, and 10 were considered as controls. In all the subjects, the IL-1 levels were increased significantly both at 6 ( p = 0.013) and 24 h ( p = .005) after the A. fumigatus challenge compared to placebo. In subjects with previous occupational exposure in a moisture-damaged building, IL-4 concentrations were increased significantly both at 6 ( p = .046) and 24 h ( p = .008) after the A. fumigatus challenge compared with placebo. Furthermore, in the control group, TNF- α levels were significantly increased at 6 h after the A. fumigatus challenge compared to placebo ( p = .028). Thus, these data show a link between markers of inflammation in NAL and experimental A. fumigatus challenge.
Document Type: Research Article
Publication date: December 1, 2006