Seasonal Allergic Rhinitic and Normal Subjects Respond Differentially to Nasal Provocation with Acetic Acid Vapor

Authors: shusterman, Dennis¹; Tarun, Alice¹; Murphy, Mary²; Morris, John³

Source: Inhalation Toxicology, Volume 17, Number 3, Number 3/March 2005 , pp. 147-152(6)

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Abstract:

Individuals with seasonal allergic rhinitis (SAR) showa more marked nasal obstructive response (increases in nasal airways resistance or NAR) after provocation with chlorine gas (Cl2) than do nonrhinitic (NR) controls. We were interested in learning whether similar differential respon-siveness was apparent after provocation with acetic acid vapor. Sixteen nonsmoking, nonasth-matic subjects, aged 21-63 yr, equally divided by gender and nasal allergy status, were enrolled in a single-blinded crossover study involving exposure to acetic acid (AA) vapor (15 ppm) or air for 15 min on separate days 1 wk apart. NAR was measured in triplicate before, immedi-ately post-, and 15 min postexposure, was normalized to baseline on a given exposure day, and was expressed as Net [NAR/baseline] after acetic acid versus control (air) exposure. After log transformation to achieve normality, the mean loge of Net [NAR/baseline] was 0.22 for SAR subjects and -0.11 for NR subjects immediately postexposure (p

Document Type: Research article

DOI: http://dx.doi.org/10.1080/08958370590904508

Affiliations: 1: Department of Medicine, University of California, San fracisco, California, USA 2: Department of Pediatics, University of California, San fracisco, California, USA 3: Department of Pharmaceutical Science, University of Connecticut, Storrs, Connecticut, USA

Publication date: 2005-03-01

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