MICRONUCLEI INDUCED BY SULFUR DIOXIDE INHALATION IN MOUSE BONE-MARROW CELLS IN VIVO

Authors: Meng, Ziqiang; Zhang, Bo; Ruan, Aidong; Sang, Nan; Zhang, Jianbiao

Source: Inhalation Toxicology, Volume 14, Number 3, 1 March 2002 , pp. 303-309(7)

Publisher: Informa Healthcare

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Abstract:

Induction effects of sulfur dioxide (SO2) inhalation on micronuclei (MN) formation in the polychromatic erythrocytes (PCE) of mouse bone marrow were studied in vivo. It was shown that SO2 inhalation caused an increase of MN frequencies in the PCE cells in a dose-dependent manner. These results from male and female mice were very similar; no sex difference was observed. These results imply that SO2 is a clastogenic and genotoxic agent.

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/08958370252809077

Affiliations: Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China

Publication date: March 1, 2002

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