ESTIMATING ROCK AND SLAG WOOL FIBER DISSOLUTION RATE FROM COMPOSITION

Authors: Eastes, Walter; Potter, Russell M.; Hadley, John G.

Source: Inhalation Toxicology, Volume 12, Number 12, 10 December 2000 , pp. 1127-1139(13)

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Abstract:

A method was tested for calculating the dissolution rate constant in the lung for a wide variety of synthetic vitreous silicate fibers from the oxide composition in weight percent. It is based upon expressing the logarithm of the dissolution rate as a linear function of the composition and using a different set of coefficients for different types of fibers. The method was applied to 29 fiber compositions including rock and slag fibers as well as refractory ceramic and special-purpose, thin E-glass fibers and borosilicate glass fibers for which in vivo measurements have been carried out. These fibers had dissolution rates that ranged over a factor of about 400, and the calculated dissolution rates agreed with the in vivo values typically within a factor of 4. The method presented here is similar to one developed previously for borosilicate glass fibers that was accurate to a factor of 1.25. The present coefficients work over a much broader range of composition than the borosilicate ones but with less accuracy. The dissolution rate constant of a fiber may be used to estimate whether disease would occur in animal inhalation or intraperitoneal injection studies of that fiber.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/08958370050198502

Affiliations: 1: Owens-Corning, Science and Technology Center, Granville, Ohio, USA

Publication date: 2000-12-10

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