ANIMAL MODELS OF CARDIAC DISEASE: Potential Usefulness for Studying Health Effects of Inhaled Particles

Authors: Muggenburg, Bruce A.; Tilley, Larry; Green, Francis H.Y.

Source: Inhalation Toxicology, Volume 12, Number 9, 1 September 2000 , pp. 901-925(25)

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Abstract:

Cardiac disease is one of the major causes of morbidity and mortality worldwide and is the leading cause of death in the United States. Epidemiologic studies have shown a close association between morbidity and mortality from cardiac disease, primarily in persons already affected, and with modest increases in levels of air pollution. At present, no mechanisms are known by which inhaled air pollutants interact with the heart to cause death. Thus, animal models of cardiac disease are needed to study possible interactions between inhaled pollutants and the heart and the resultant morbidity and mortality. Very little research in animals has been conducted in this area, and appropriate animal models must be carefully selected. The purpose of this review is to examine several potential animal models and to discuss their advantages and disadvantages in the study of cardiac disease and air pollution.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/08958370050123225

Publication date: 2000-09-01

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