INHALED PARTICLE-BOUND SULFATE: Effects on Pulmonary Inflammatory Responses and Alveolar Macrophage Function

Authors: Clarke, Robert W.; Antonini, James M.; Hemenway, David R.; Kleeberger, Steven R.; Jakab, George J.

Source: Inhalation Toxicology, Volume 12, Number 3, 1 March 2000 , pp. 169-186(18)

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Abstract:

Acid sulfate-coated solid particles are a significant environmental hazard produced primarily by the combustion of fossil fuels. We have previously described a system for the nascent generation of carbonaceous particles surface coated with approximately 140 mug/ m3 acid sulfate [cpSO₄^2-; 10 mg/m³ carbon black (CB) and 10 ppm sulfur dioxide (SO2) at 85% relative humidity (RH)]. The effects of inhaled cpSO₄^2- on pulmonary host defenses are assessed in the present work. Mice were acutely exposed (4 h) to either 10 mg/m3 CB, 10 ppm SO_2, or their combination at 10% or 85% RH in a nose-only inhalation chamber. No evidence of an inflammatory response was found following any of the exposures as assessed by total cell counts and differential cell counts from bronchoalveolar lavage fluid. However, alveolar macrophage Fc receptor-mediated phagocytosis decreased only following exposure to 140 mug cpSO₄^2-, significant suppression occurred after 24 h, maximal suppression occurred at 3 days postexposure, and recovery to preexposure levels required 7-14 days. Intrapulmonary bactericidal activity (IBA) was also suppressed only after exposure to 140 mug cpSO₄^2-; suppression was maximal at 1 day postexposure and recovered by day 7. To assess the effects of lower cpSO₄^2- concentrations, mice were repeatedly exposed to 1 mg/m3 CB and 1 ppm SO2 at 85% RH (20 mug/m3 cpSO₄^2- for 4 h/day) for up to 6 days. A significant decrement in IBA was observed following 5 and 6 days of exposure. These studies indicated that acute or repeated exposure to cpSO₄^2- could alter pulmonary host defense mechanisms.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/089583700196220

Publication date: 2000-03-01

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INHALED PARTICLE-BOUND SULFATE: Effects on Pulmonary Inflammatory Responses and Alveolar Macrophage Function

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