Cancer risk is not increased after conventional hip arthroplasty
Source: Acta Orthopaedica, Volume 81, Number 1, February 2010 , pp. 77-81(5)
Publisher: Informa Healthcare
Background and purpose Wear debris from conventional total hip arthroplasty (THA) induces chromosomal aberrations and DNA damage, which may promote cancerogenesis. A long latent period is required for solid tumors. We therefore re-analyzed a large THA cohort for cancer.
Patients and methods We updated a cohort of 24,636 patients with primary osteoarthritis and metal-on-polyethylene THA who had been entered in the Finnish Arthroplasty Register between 1980 and 1995, and linked it to the Finnish Cancer Registry for cancer risk assessment up to 2005. The mean follow-up time was 13 years. The numbers of cancer cases observed were compared with expected rates based on incidence in the general population.
Results The standardized incidence ratio (SIR) for the whole follow-up period was 0.95 (95% confidence interval (CI): 0.92––0.97). After 10 years of follow-up, the SIR was equal to that in the normal population (SIR == 0.98, 95% CI: 0.94––1.03). Incidence of lung cancer was low throughout the follow-up time and that of prostate cancer was slightly elevated. The incidence rates for all other forms of cancer did not deviate significantly from those in the normal population.
Interpretation We found no increased cancer risk in patients with conventional THA after an average of 13 years and up to 25 years of follow-up.
Document Type: Research Article
Affiliations: 1: 1Research Department, Centre for Military Medicine 2: 2Department of Public Health, University of Helsinki 3: 3Hospital Orton 4: 4Finnish Cancer Registry, Helsinki and School of Public Health, University of Tampere, Finland
Publication date: February 1, 2010