Metalloproteinases and their inhibitors—diagnostic and therapeutic opportunities in orthopedics
Authors: Pasternak, Björn; Aspenberg, Per
Source: Acta Orthopaedica, Volume 80, Number 6, December 2009 , pp. 693-703(11)
Publisher: Informa Healthcare
Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice.
Document Type: Research Article
Affiliations: 1Orthopaedics and Sports Medicine, IKE, Linköping University, Linköping
Publication date: 2009-12-01