Free Content

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

Authors: Baas, Jorgen1; Elmengaard, Brian1; Bechtold, Joan2; Chen, Xinqian2; Søballe, Kjeld1

Source: Acta Orthopaedica, Volume 79, Number 6, December 2008 , pp. 841-850(10)

Publisher: Informa Healthcare

Buy & download fulltext article:

Free content The full text is free.

View now:


Background and purpose We studied whether osseointegration and fixation of plasma-sprayed titanium implants grafted with -TCP granules (Ossaplast) can be improved by adding an osteogenic signal (Colloss E). The results were compared to implants grafted with fresh frozen morselized allograft with and without the Colloss E device. Methods 4 porous-coated Ti implants were placed in the proximal humeri in each of 10 dogs. All implants were surrounded by a 2.5-mm defect, which was grafted with: (A) -TCP, (B) -TCP+20 mg Colloss E, (C) allograft, or (D) allograft+20 mg Colloss E. The observation time was 4 weeks. Results Mechanical testing showed that the -TCP group with Colloss E was twice as well fixed as the control group grafted with -TCP granules alone, and comparable to both allograft groups. We found that every control implant in the -TCP grafted group was covered by a dense fibrous membrane. No fibrous tissue was seen in the -TCP group augmented with Colloss. These implants were well osseointegrated, with new bone covering 10-25% of the implant surface. Both treated groups had increased graft resorption compared to their respective control groups. Colloss E had no effect on new bone formation or fibrous tissue reduction around the allografted implants. Interpretation The Colloss E device improved early osseointegration of implants grafted with -TCP granules and increased their mechanical implant fixation to the level of allografted implants. The experiment indicates that ceramic bone substitutes may be a viable alternative to allograft when combined with an osteogenic signal such as Colloss E.

Document Type: Research Article


Affiliations: 1: Orthopedic Research Laboratory, Aarhus University Hospital, Denmark 2: Midwest Orthopaedic Foundation and Minneapolis Medical Research Foundation, Minneapolis, MN, USA

Publication date: December 1, 2008

More about this publication?
Related content


Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page