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Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

Authors: Baas, Jorgen1; Elmengaard, Brian1; Bechtold, Joan2; Chen, Xinqian2; Søballe, Kjeld1

Source: Acta Orthopaedica, Volume 79, Number 6, December 2008 , pp. 841-850(10)

Publisher: Informa Healthcare

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Abstract:

Background and purpose We studied whether osseointegration and fixation of plasma-sprayed titanium implants grafted with -TCP granules (Ossaplast) can be improved by adding an osteogenic signal (Colloss E). The results were compared to implants grafted with fresh frozen morselized allograft with and without the Colloss E device. Methods 4 porous-coated Ti implants were placed in the proximal humeri in each of 10 dogs. All implants were surrounded by a 2.5-mm defect, which was grafted with: (A) -TCP, (B) -TCP+20 mg Colloss E, (C) allograft, or (D) allograft+20 mg Colloss E. The observation time was 4 weeks. Results Mechanical testing showed that the -TCP group with Colloss E was twice as well fixed as the control group grafted with -TCP granules alone, and comparable to both allograft groups. We found that every control implant in the -TCP grafted group was covered by a dense fibrous membrane. No fibrous tissue was seen in the -TCP group augmented with Colloss. These implants were well osseointegrated, with new bone covering 10-25% of the implant surface. Both treated groups had increased graft resorption compared to their respective control groups. Colloss E had no effect on new bone formation or fibrous tissue reduction around the allografted implants. Interpretation The Colloss E device improved early osseointegration of implants grafted with -TCP granules and increased their mechanical implant fixation to the level of allografted implants. The experiment indicates that ceramic bone substitutes may be a viable alternative to allograft when combined with an osteogenic signal such as Colloss E.

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/17453670810016948

Affiliations: 1: Orthopedic Research Laboratory, Aarhus University Hospital, Denmark 2: Midwest Orthopaedic Foundation and Minneapolis Medical Research Foundation, Minneapolis, MN, USA

Publication date: December 1, 2008

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