Effect of microfluidization parameters on the physical properties of PEG-PLGA nanoparticles prepared using high pressure microfluidization

Authors: Sani, Shabnam¹; Das, Nandita²; Das, Sudip²

Source: Journal of Microencapsulation, Volume 26, Number 6, September 2009 , pp. 556-561(6)

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Abstract:

The objective of this work was to develop uniformly distributed poly(ethylene glycol) grafted poly(lactide-co-glycolide) (PEG-PLGA) nanoparticles of mean size range ∼100-200 nm using ethyl acetate as the solvent. In the multiple emulsion solvent evaporation method a high pressure microfluidization process was adopted to produce the W/O/W multiple emulsion. Non-toxic ethyl acetate was used to solubilize PEG-PLGA. The mean size of nanoparticles obtained was less than 180 nm. The particle size and size distribution were dependent on the microfluidization conditions applied. Mean particle size steadily increased from 121 nm at three passes to 172 nm at 20 passes of the microfluidizer, indicating that over-processing may be detrimental to PEG-PLGA nanoparticles prepared using this technique. There was no significant alteration of the PEG-PLGA matrix, as evidenced from the differential scanning calorimetric studies.

Keywords: Nanoparticle; microfluidization; poly(ethylene glycol) grafted poly(lactide-co-glyc; ethyl acetate

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802500655

Affiliations: 1: Department of Pharmaceutical Sciences, Idaho State University, Pocatello, ID, USA,Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA 2: Department of Pharmaceutical Sciences, Butler University, Indianapolis, IN, USA

Publication date: 2009-09-01

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