Authors: da Silva, Classius Ferreira¹; Severino, Patricia²; Martins, Fernanda²; Chaud, Marco Vinicius³; Santana, Maria Helena Andrade²

Source: Journal of Microencapsulation, Volume 26, Number 6, September 2009 , pp. 523-528(6)

Publisher: Informa Healthcare

Abstract:

The aim of this research is to evaluate the intestinal permeation of a new formulation (NF) for the anti-retroviral didanosine (ddI) drug, using the everted gut sac model. The NF is composed by granules containing ddI incorporated in chitosan microspheres, plus free chitosan as an excipient. The permeation was evaluated across the three intestinal segments of adult male Wistar rats. The performance of ddI permeation from the NF was compared to the same granules without free chitosan and to buffered ddI tablets as control. The permeations across duodenum were higher than across jejune and ileum. The ddI from NF presented higher permeation and a crescent-shaped profile in duodenum compared to the other formulations. Such effects are provided by the superior mucoadhesiveness to the intestinal membrane and potentialize sustained release properties for NF. These results lead one to consider the novel formulation to be promising for ddI administration by oral route.

Keywords: Didanosine; chitosan microspheres; granules; everted gut sac model; intestinal absorption

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802466691

Affiliations: 1: Biotechnological Processes Development Laboratory, School of Chemical Engineering, State University of Campinas-UNICAMP, Campinas, SP, Brazil,Science and Technology Center, State University of West of Parana-UNIOESTE, Toledo, PR, Brazil 2: Biotechnological Processes Development Laboratory, School of Chemical Engineering, State University of Campinas-UNICAMP, Campinas, SP, Brazil 3: School of Health Sciences, Methodist University of Piracicaba-UNIMEP, Piracicaba, SP, Brazil

Publication date: 2009-09-01

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