Authors: Gifani, Aida¹; Taghizadeh, Mojtaba²; Seifkordi, Ali³; Ardjmand, Mehdi⁴

Source: Journal of Microencapsulation, Volume 26, Number 6, September 2009 , pp. 485-492(8)

Publisher: Informa Healthcare

Abstract:

Salicylic acid-beeswax microspheres were prepared by melt dispersion technique. The effects of formulation parameters on the microscopic characteristic, drug loading and cumulative amount of released drug were investigated by experimental design. Results showed that all of the microparticles were spherical with porous surfaces. The average size of microspheres was 24-48 µm, the drug content was in the range of 22-45% and the encapsulation efficiency was 46-93%. Drug loading was influenced by emulsification speed as a main factor. All the microspheres had a burst release initially. The emulsifier concentration did not have a significant effect on drug release. The release behaviour of microspheres conformed best to Korsmeyer-Peppas semi-empirical model and the release of SA from beeswax microspheres was Fickian (n < 0.45).

Keywords: Salicylic acid; beeswax; microsphere; sustained release; experimental design

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802413107

Affiliations: 1: Islamic Azad University, Science and Research Branch, Tehran, Iran 2: Science Faculty, Department of Novel Drug Delivery Systems, Iran Polymer & Petrochemical Institute, Tehran, Iran 3: Department of Chemical & Petroleum Engineering, Sharif University of Technology, IR, Iran 4: Graduate Faculty, Department of Chemical Engineering, Azad Islamic University, Tehran South Branch, Iran

Publication date: 2009-09-01

More about this publication?

• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Gifani, Aida ;  Taghizadeh, Mojtaba ;  Seifkordi, Ali ;  Ardjmand, Mehdi

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers