Authors: Lira, Ana Amelia; Rossetti, Fabia; Nanclares, Denise; Neto, Alberto Federman; Bentley, Maria Vitoria; Marchetti, Juliana

Source: Journal of Microencapsulation, Volume 26, Number 3, May 2009 , pp. 243-250(8)

Publisher: Informa Healthcare

Abstract:

Chitosan treated alginate microparticles were prepared with the purpose of incorporating all-trans retinoic acid (ATRA) using an inexpensive, simple and fast method, enhancing dermal localization and sustaining the release of ATRA into the skin. Microparticles characterization, drug-polymer interaction, release profile and in vitro skin retention were investigated. Microparticles presented spherical shape and drug loading capacity of 47%. The drug content of these microparticles was affected by ATRA concentration and by the solvent used and it was more weakly affected by chitosan concentration. The release of ATRA was also affected by chitosan concentration. Microparticles prepared with 0.4% chitosan (w/w) resulted in drug release with a more sustained profile. The results of in vitro retention studies showed that chitosan treated alginate microparticles decreased the drug retention in the stratum corneum (SC), where occur the skin irritation, but maintained the ATRA concentration in the deeper skin layers, where occur the pathologies treated with ATRA. Then, the microparticles developed in this work can be a good candidate to improve the topical therapy with retinoid.

Keywords: Microparticles; alginate; chitosan; all-trans retinoic acid; skin delivery

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802305105

Affiliations: 1: Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

Publication date: 2009-05-01

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