Authors: Nayak, Usha Yogendra¹; Gopal, Shavi¹; Mutalik, Srinivas²; Ranjith, Averinen Kumar¹; Reddy, Meka Sreenivasa¹; Gupta, Purushotham¹; Udupa, Nayanabhirama¹

Source: Journal of Microencapsulation, Volume 26, Number 3, May 2009 , pp. 214-222(9)

Publisher: Informa Healthcare

Abstract:

Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2% acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60-210 µm, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60% of entrapment and release was extended up to 18-24 h. Among all the systems studied, the 35% Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75% release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drug-polymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.

Keywords: Zidovudine; microspheres; chitosan; glutaraldehyde; kinetic models

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802246325

Affiliations: 1: Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576104, India 2: School of Pharmacy, University of Queensland, Brisbane, Qld 4072, Australia

Publication date: 2009-05-01

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