Authors: Thaurer, Michael¹; Deutel, Britta¹; Schlocker, Wolfgang²; Bernkop-Schnurch, Andreas²

Source: Journal of Microencapsulation, Volume 26, Number 3, May 2009 , pp. 187-194(8)

Publisher: Informa Healthcare

Abstract:

In this study the preparation and stabilization of poly(acrylic acid)-cysteine nanoparticles and incorporation of a fluorescence marked model-compound was investigated. Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-cysteine nanoparticles display high cohesive properties due to a cross-linking process via calcium bridges in the core and the pervasive formation of disulphide bonds and were 139 ± 34 nm in size. Nanoparticles were loaded with FITC-dextrans (flourescein isothiocyanate-dextrans) of 4, 20 and 40 kDa molecular mass as model-compound via sonication method or via vibration method for 3 and 24 h. In vitro release studies showed an initial burst release followed by an extended release of model-compounds. The lower the molecular mass of the FITC-dextrans, the higher was the amount of incorporated and released model compounds. Vibration seems to be a proper method for the incorporation of hydrophilic and macromolecular drugs in poly(acrylic acid)-cysteine nanoparticles.

Keywords: Nanoparticles; ionic gelation; thiomers; mucoadhesion; poly(acrylic acid); cross-linking

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802217003

Affiliations: 1: ThioMatrix GmbH, Research Center, Innsbruck, Austria 2: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University Innsbruck, Innsbruck, Austria

Publication date: 2009-05-01

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