Effect of drying processes and curing time of chitosan-lysine semi-IPN beads on chlorpheniramine maleate delivery

Authors: Kumari, K.; Kundu, P. P.

Source: Journal of Microencapsulation, Volume 26, Number 1, February 2009 , pp. 54-62(9)

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Abstract:

Beads of semi-interpenetrating polymer network (semi-IPN) have been synthesized from chitosan and lysine with varying amounts of glutaraldehyde solution used as a cross-linker. The cross-linked beads are dried by different drying processes such as air-drying, oven-drying and freeze-drying. These semi-IPNs are characterized under a scanning electron microscope (SEM). Swelling studies of these beads are carried out in different pH (2.0 and 7.4) solutions. The effect of concentration of cross-linking agent and curing period on the swelling as well as on the drug release is analysed. The results indicate that the size of matrix depend on the curing time of beads, concentration of glutaraldehyde and technique of drying. The freeze-dried beads exhibit a relatively higher percentage of swelling in the range of 66-89% as compared to oven-dried beads (53-74%) and air-dried beads (39-61%). The drug loaded beads which are cured for different time intervals followed by drying are tested for in-vitro release of chlorpheniramine maleate (CPM) drug. The rate of drug release from freeze-dried beads is much faster than that from the oven-dried and air-dried beads.

Keywords: Chitosan; lysine; controlled drug release; IPNs; cross-linking; freeze-drying

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652040802137110

Affiliations: 1: Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal, India

Publication date: 2009-02-01

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