Authors: Biolo, Andreia; Rohde, Luis; Goldraich, Livia; Mascarenhas, Marcello; Palombini, Dora; Clausell, Nadine

Source: Biomarkers, Volume 14, Number 6, September 2009 , pp. 438-442(5)

Publisher: Informa Healthcare

Abstract:

Elevated filling pressures are associated with heart failure deterioration, but mechanisms underlying this association remain poorly understood. We sought to investigate whether or not elevated filling pressures are associated with increased collagen turnover, evaluated by procollagen type III aminoterminal peptide (PIIINP) levels, in stable systolic heart failure. Eighty patients with heart failure with severe systolic dysfunction (ejection fraction 26 ± 7%) were included. Patients underwent simultaneous echocardiogram with evaluation of haemodynamic parameters and blood sampling for PIIINP measurement. Mean PIIINP level was 6.11 ± 2.62 μg l-1. PIIINP was positively associated with estimated right atrial pressure (RAP) (r = 0.36; p = 0.001). Mean PIIINP values were 5.04 ± 2.42 μg l-1 in patients with estimated RAP ≤ 5 mmHg, and 7.59 ± 2.54 μg l-1 in those with RAP > 15 mmHg (p < 0.01). In conclusion, elevated right-side filling pressures are associated with evidence of active extracellular matrix turnover, as indicated by elevated PIIINP levels, in stable systolic heart failure. Activation of extracellular matrix turnover may be implicated in the accelerated progression of heart failure syndromes seen in patients with persistent congestion.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/13547500903098293

Affiliations: 1: Division of Cardiology, Hospital de Clinicas de Porto Alegre, Post-graduate Program of Cardiovascular Sciences: Cardiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

Publication date: 2009-09-01

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