IngentaConnect Donepezil mediated memory improvement in traumatic brain injury d...

Authors: Taverni J. P.; Seliger G.; Lichtman S. W.

Source: Brain Injury, Volume 12, Number 1, 1 January 1998 , pp. 77-80(4)

Abstract:

Memory dysfunction is a recognized and difficult to treat complication of traumatic brain injury TBI . Since medial temporal lobe injury is a frequent contributor to memory dysfunction in TBI, it is likely that an acetylcholine deficit contributes to memory dysfunction in this population. Recently, Donepezil, an acetylcholine esterase inhibitor which has demonstrated a high selectivity for neural Ach esterase with minimal side effects , was approved for use in dementia in Alzheimer s patients. Due to its promising results in Alzheimer s patients, and reports in the literature describing the use of physostigmine an anti cholinesterase with significant cardiovascular and autonomic side effects to treat memory deficits in closed head injury, we decided to begin a trial of Donepezil in two patients with TBI who were experiencing long term static memory dysfunction refractory to conventional treatment. Both patients were admitted to our facility for physical and cognitive rehabilitation, and were started on a trial of Donepezil. Modified memory tests and subjective observations by both family and staff pointed to an improvement in memory within three weeks of starting Donepezil. Should these initial results be supported in larger trials, Donepezil may prove to be a valuable tool for the treatment of memory dysfunction in TBI.

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Donepezil mediated memory improvement in traumatic brain injury during post acute rehabilitation