Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin

Authors: Hayashi, Tetsuo; Yoshida, Soichiro; Yoshinaga, Atushi; Ohno, Rena; Ishii, Nobuyuki; Yamada, Takumi

Source: Scandinavian Journal of Urology and Nephrology, Volume 39, Number 5, November 2005 , pp. 431-432(2)

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Abstract:

We present two cases of infertile male patients with oligoasthenozoospermia who were receiving anti-epilepsy medication. Complete reversal of the spermatic dysfunction followed by a successful conception was achieved after discontinuation of sodium valproate, suggesting that the drug was responsible for spermatic dysfunction in these individuals.

Keywords: Epilepsy; infertility; sperm

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365590500252688

Affiliations: 1: Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan

Publication date: 2005-11-01

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