Cardiovascular complications in patients with advanced prostatic cancer treated by means of orchiectomy or polyestradiol phosphate

Authors: Mikkola, Arto; Aro, Jussi; Rannikko, Sakari; Oksanen, Hanna; Ruutu, Mirja; behalf of the finnprostate group, On

Source: Scandinavian Journal of Urology and Nephrology, Volume 39, Number 4, September 2005 , pp. 294-300(7)

Publisher: Informa Healthcare

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Abstract:

Objective To evaluate the cardiovascular (CV) complications associated with orchiectomy (OE) and parenteral polyestradiol phosphate (PEP) therapy (240 mg/month), taking into account the effect of pretreatment diseases and pretreatment medication. Material and methods A total of 244 T3–4 M0 patients and 200 T1–4 M1 patients were randomized to either OE or PEP therapy. The two groups of patients were analyzed separately. The follow-up period was 36 months. The effect of pretreatment vascular and other diseases and pretreatment medication which may be associated with a risk of CV complications was evaluated. Results In the T3–4 M0 patients, the treatment (PEP versus OE) and the presence of pretreatment vascular diseases were statistically significantly associated with a risk of CV complications ( p =0.01 and 0.003, respectively). In the T1–4 M1 patients, such an association was not found. No association was observed between pretreatment medication and CV complications. There was no difference in progression-free time between the therapy groups in either the T3–4 M0 or T1–4 M1 patients. Conclusion In patients with locally advanced prostatic cancer, PEP therapy is associated with a statistically significantly higher risk of CV complications compared to OE.

Keywords: Cardiovascular complications; parenteral estrogen; progression; prostatic cancer; therapy

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365590510031228

Affiliations: 1: Department of Urology, Helsinki University Central Hospital, Helsinki, Finland

Publication date: 2005-09-01

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