Cardiovascular complications in patients with advanced prostatic cancer treated by means of orchiectomy or polyestradiol phosphate
Authors: Mikkola, Arto; Aro, Jussi; Rannikko, Sakari; Oksanen, Hanna; Ruutu, Mirja; behalf of the finnprostate group, On
Source: Scandinavian Journal of Urology and Nephrology, Volume 39, Number 4, September 2005 , pp. 294-300(7)
Publisher: Informa Healthcare
Abstract:
Objective To evaluate the cardiovascular (CV) complications associated with orchiectomy (OE) and parenteral polyestradiol phosphate (PEP) therapy (240 mg/month), taking into account the effect of pretreatment diseases and pretreatment medication. Material and methods A total of 244 T34 M0 patients and 200 T14 M1 patients were randomized to either OE or PEP therapy. The two groups of patients were analyzed separately. The follow-up period was 36 months. The effect of pretreatment vascular and other diseases and pretreatment medication which may be associated with a risk of CV complications was evaluated. Results In the T34 M0 patients, the treatment (PEP versus OE) and the presence of pretreatment vascular diseases were statistically significantly associated with a risk of CV complications ( p =0.01 and 0.003, respectively). In the T14 M1 patients, such an association was not found. No association was observed between pretreatment medication and CV complications. There was no difference in progression-free time between the therapy groups in either the T34 M0 or T14 M1 patients. Conclusion In patients with locally advanced prostatic cancer, PEP therapy is associated with a statistically significantly higher risk of CV complications compared to OE.Keywords: Cardiovascular complications; parenteral estrogen; progression; prostatic cancer; therapy
Document Type: Research article
DOI: http://dx.doi.org/10.1080/00365590510031228
Affiliations: 1: Department of Urology, Helsinki University Central Hospital, Helsinki, Finland
Publication date: 2005-09-01
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- By this author: Mikkola, Arto ; Aro, Jussi ; Rannikko, Sakari ; Oksanen, Hanna ; Ruutu, Mirja ; behalf of the finnprostate group, On

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