Expression of matrix metalloproteinase-9 (MMP-9) and blood vessel density in laryngeal squamous cell carcinomas

Authors: Wittekindt, Claus¹; Jovanovic, Nebojsa²; Guntinas-Lichius, Orlando³

Source: Acta Oto-Laryngologica, Volume 131, Number 1, January 2011 , pp. 101-106(6)

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Abstract:

<title>Abstract</title>

Conclusion: In this study we found that inflammatory cells may be a source of MMP-9 in laryngeal cancer. MMP-9 was correlated with blood vessel density. MMP-9 may be a potential target to disrupt tumor neovascularization. Objective: To study the expression of MMP-9 in laryngeal cancer and determine a possible relation with blood vessel density. Methods: Immunohistochemistry was used for MMP analysis and for blood vessel detection in 83 laryngeal cancer samples. The density of blood vessels was analyzed with a stereological tool. Results: MMP-9 was detected in inflammatory cells. Positivity for MMP-9 correlated significantly with the grade of differentiation (p == 0.025). Expression of MMP-9 was not correlated with T stage, nodal metastasis, or tumor recurrence. The mean blood vessel density was 51.4 vessels/mm². Specimens were more likely to exhibit higher density of blood vessels when MMP-9 expression was also present (p == 0.014).

Keywords: Matrix metalloproteinases; laryngeal cancer; immunohistochemistry

Document Type: Research article

DOI: http://dx.doi.org/10.3109/00016489.2010.506886

Affiliations: 1: 1Department of Otorhinolaryngology, Justus Liebig University, Giessen 2: 2Department of Otorhinolaryngology, Friedrich-Schiller-University Jena 3: 3Department of Otorhinolaryngology, University of Aachen, Germany

Publication date: 2011-01-01

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