Intratympanic prednisolone therapy for sudden sensorineural hearing loss: A new protocol
Authors: Filipo, Roberto; Covelli, Edoardo; Balsamo, Giorgio; Attanasio, Giuseppe
Source: Acta Oto-Laryngologica, Volume 130, Number 11, November 2010 , pp. 1209-1213(5)
Publisher: Informa Healthcare
Conclusion: Intratympanic administration of prednisolone at a dose of 62.5 mg/ml performed every day for 3 consecutive days is more efficacious than the therapeutic approaches described so far in the literature. Objectives: The aim of the study was to evaluate the overall success rate, morbidity, and prognostic factors of a new protocol of intratympanic steroid administration as a means of primary therapy for idiopathic sensorineural hearing loss. Methods: Overall, 34 patients presenting sudden unilateral sensorineural hearing loss of at least 30 dB over three frequencies that had developed within 72 h were treated once a day for 3 consecutive days with a single intratympanic injection of prednisone diluted in saline solution. Results: Following intratympanic therapy with prednisone, 16 patients (47%) reported complete recovery of sudden sensorineural hearing loss, with a pure tone average that returned within 25 dB; 11 patients (32.3%) showed improvement in hearing of more than 30 dB; 4 patients presented improvement in pure-tone average between 10 and 30 dB. Only three patients failed to improve following intratympanic injection.
Document Type: Research Article
Affiliations: Department of Neurology and Otolaryngology, ‘sapienza’ University of Rome, Rome, Italy
Publication date: November 2010