Differential Expression Pattern of Cyclooxygenase-1 and -2 in Head and Neck Squamous Cell Carcinoma
Source: Acta Oto-Laryngologica, Volume 123, Number 8, October 2003 , pp. 950-953(4)
Publisher: Informa Healthcare
Abstract:Objective--The enzyme cyclooxygenase catalyzes the first step of the synthesis of prostanoids. Cyclooxygenase has been shown to exist in two distinct isoforms: cyclooxygenase-1 is constitutively expressed as a housekeeping enzyme in most tissues whereas the inducible cyclooxygenase-2 has been reported to be involved in inflammatory processes and in the carcinogenesis of squamous cell carcinoma. The aim of this study was to investigate the distribution patterns of cyclooxygenase-1 and -2 in peritumoral lymphocytic infiltrates and tumor cells of head and neck carcinoma. Material and Methods--Immunohistochemical analysis was performed using paraffin-embedded tumor specimens from 24 patients suffering from oropharyngeal, hypopharyngeal and oral squamous cell carcinomas. Results--We observed that cyclooxygenase-2 immunoreactivity, compared to that of cyclooxygenase-1, was significantly increased in peritumoral lymphocytic infiltrates as well as in tumor cells. Conclusion--The expression of cyclooxygenase-2 in both tumor specimens and the surrounding peritumoral lymphocytic infiltrates supports the hypothesis that cyclooxygenase may be one of several important links between chronic inflammation and carcinogenesis.
Document Type: Research Article
Affiliations: 1: Otorhinolaryngology, Head and Neck Surgery University of Vienna Medical School Vienna 2: Radiotherapy University of Vienna Medical School Vienna 3: Maxillofacial Surgery University of Vienna Medical School Vienna 4: Clinical Pathology University of Vienna Medical School Vienna
Publication date: 2003-10-01