The Effect of Forskolin on the Sound-evoked Potentials in the Guinea Pig Cochlea

Authors: Kitano, Ikuo; Mori, Nozomu; Nario, Kazuhiko; Doi, Katsumi; Matsunaga, Takashi

Source: Acta Oto-Laryngologica, Volume 118, Supplement 533, 27 May 1998 , pp. 4-8(5)

Publisher: Informa Healthcare

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The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2×10-4 M) produced a significant increase in the amplitude of negative summating potential (−SP) with no change in cochlear microphonics (CM) amplitude, and a significant decrease in the amplitude of compound action potential (CAP) with a significant prolongation of N1 latency and a 20 dB CAP threshold elevation. The results lead us to speculate that FSK-induced changes may be involved in the transient formation of endolymphatic hydrops.

Document Type: Regular Paper


Publication date: May 27, 1998

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