Volume specific response criteria for brain metastases following salvage stereotactic radiosurgery and associated predictors of response
Source: Acta Oncologica, Volume 51, Number 5, May 2012 , pp. 629-635(7)
Publisher: Informa Healthcare
Background. We aimed to derive three-dimensional volume-based (V3D) response criteria that approximate those based on Response Evaluation Criteria in Solid Tumours (RECIST) in patients with brain metastases (BM) treated with salvage stereotactic radiosurgery (SRS). Material and methods. Seventy patients with 178 BM were treated with SRS. Each BM was characterised at baseline and at each follow-up MRI according to its widest diameter and V3D using ITK-SNAP image segmentation software. Results. The median tumour diameter was 1.2 cm (range, 0.2–4.5 cm) and V3D was 0.73 cm3 (range, 0.01–22.7 cm3). The V3D percent changes that best matched RECIST response criteria were: an increase of ≥71.5% for progressive disease, a ≥58.5% decrease for partial response and a <58.5% decrease or increase of <71.5% for stable disease (k =0.85). A baseline diameter >3.0 cm (p =0.006) and a V3D >6.0 cm3 (p =0.043) predicted for local failure, and a baseline cumulative V3D of >3.0 cm3 (p =0.02) was adversely prognostic for survival. Conclusions. We define 3D volume specific criteria to base response upon for brain metastases treated with salvage SRS. Tumours with a V3D of greater than 6 cm3 are at a higher risk of local failure.
Document Type: Research Article
Affiliations: 1: 1Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada 2: 2Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada 3: 3Department of Biostatistics, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada 4: 4Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Publication date: May 1, 2012